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If Your Mother Had Alzheimer’s, You Are More At Risk

A new study published in the ‘Neurology’ journal claims that those with a maternal history of Alzheimer’s exhibited twice the level of brain shrinkage than those with no history.  Alzheimer’s disease, of course, causes significant brain shrinkage in its victims.

This startling study by Robyn Honea, DPhil, claims that the findings suggest that those with a mother who suffered Alzheimer’s demonstrate much more brain shrinkage per year than those who had a father with the disease, or no parental history at all.

The Alzheimer’s Association, who have reviewed the study, maintain that the sample size for the study was too small to deliver conclusive findings.  Only 53 people were assessed in the research.

However, the findings are supported by the National Institute on Aging and the National Institute of Neurological Disorders.

Of the 53 subjects in the study, all were over 60 years, and cognitively healthy at the beginning of the research. 11 people had a maternal family history of Alzheimer’s, 10 had a paternal history and the remaining 32 had no parental history whatsoever.

Initially all the subjects were tested on their memory, language and cognitive skills and given brain MRI scans. Two years later the tests were repeated, and the findings form the basis of the study.

The findings were that:
Those with a maternal history had about 1.5 times more brain shrinkage per year than those with a paternal history.
Those with a mother with Alzheimer’s had twice the gray matter shrinkage than those who had no parental history, or a father with Alzheimer’s.
The subjects’ performance at the cognitive tests did not change at two years.

It seems these findings are in line with previous studies that have found maternal family history is linked to an increased risk for Alzheimer’s.  However, researchers in the field have not come up with any conclusive findings that indicate the genetic link.  

So whilst this recent study seems to have replicated previous research, the medical and scientific profession, are still campaigning for more extensive research to be conducted.

Alzheimer’s is likely to be affecting one in every four Americans over the coming decade, and so for the time-being the recommendations are to take all the preventative precautions to help delay any onset of Alzheimer’s.  Get as much regular exercise as possible, eat a healthy diet, get as much intellectual and cognitive stimulation as you can and stay socially active.


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